Revealing Hidden Variables in DESI-Based Spatial Metabolomics: Solvent Composition and Tissue Type as Critical Drivers - Giampà M, Verhaert P, Claereboudt J, Claude E, Drotleff B, Goeminne G, Heedfeld V, Idkowiak J, Jones E, Muck A, Mathys J, Othmann A, Ravoet N, Lopes-Sampaio J, Swinnen J, Jochmans I, Ghesquière B - J Proteome Res - Pubmed

The complexome contextualizes proteomics data to fingerprint biological states and highlight perturbed functional modules in disease - Guharoy M, Adant I, Bird M, Botzki A, Collier J, Dehairs J, Derveaux S, Devos S, Goeminne G, Impens F, Jáñez Pedrayes A, Janky R, Maes R, Magalhães P, Maia TM, Meersseman W, Rymen D, Swinnen JV, Van Haver D, Verdegem D, Witters P, Cassiman D, Ghesquière B. - 2026 - npj Syst Biol and Appl - PubMed

Multi-omics analysis reveals ER stress as a main feature of two endothelial cell models of N-linked congenital disorders of glycosylation - Driesen K, Holubová V, Magalhães P, Loopmans S, Guharoy M, Meyts I, Morava E, Ghesquière B, Witters P - 2026 - Mol Genet Metab - PubMed

A scalable tool for fast and flexible variant identification in mass spectrometry - Ghesquière B - 2025 - Nat Comput Sci - PubMed

Resolving Hexose-Phosphates by LC-MS Leads to New Insights in PGM1-CDG Pathophysiology - Driesen K, De Craemer S, Morava E, Cassiman D, Witters P, Ghesquière B - 2025 - ACS Publications - PubMed

Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation - Jáñez Pedrayes A, De Craemer S, Idkowiak J, Verdegem D, Thiel C, Barone R, Serrano M, Honzík T, Morava E, Vermeersch P, Foulquier F, Morelle W, Swinnen JV, Rymen D, Cassiman D, Ghesquière B, Witters P. - 2025 - Cell Mol Life Sci - PubMed

Complex Metabolomic Changes in a Combined Defect of Glycosylation and OxidativePhosphorylation in a Patient with Pathogenic Variants in PGM1 and NDUFA13 - Radenkovic S, Adant I, Bird MJ, Swinnen JV, Cassiman D, Kozicz T, Gruenert SC, Ghesquière B, Morava E - 2025 - Cells - PubMed

Wall shear stress modulates metabolic pathways in endothelial cells - Simoes Faria R, Daems M, Peacock HM, Declercq M, Willems A, Jones EAV, Ghesquière B.  - 2025 - Metabolomics - PubMed

Glycosphingolipids in congenital disorders of glycosylation (CDG) - Jáñez Pedrayes A, Rymen D, Ghesquière B, Witters P - 2024 - Molecular Genetics and Metabolism - PubMed

Neural and metabolic dysregulation in PMM2-deficient human in vitro neural models - Radenkovic S, Budhraja R, Klein-Gunnewiek T, King AT, Bhatia TN, Ligezka AN, Driesen K, Shah R, Ghesquière B, Pandey A, Kasri NN, Sloan SA, Morava E, Kozicz T. - 2024 - Cell Reports - PubMed

Ischemia-induced metabolic patterns associate with kidney function during normothermic kidney perfusion, a preclinical study- De Beule J, De Craemer S, Verstraeten L, Ghesquière B, Jochmans I - 2024 - Annals of Surgery - PubMed

Tracer metabolomics reveals the role of aldose reductase in glycosylation - Radenkovic S, Ligezka AN, Mokashi SS, Driesen K, Dukes-Rimsky L, Preston G, Owuocha LF, Sabbagh L, Mousa J, Lam C, Edmondson A, Larson A, Schultz M, Vermeersch P, Cassiman D, Witters P, Beamer LJ, Kozocs T, Flanagan-Steet H, Ghesquière B^*, Morava E^*. - 2023 - Cell Reports Medicine - PubMed

Current insights into the metabolome during hypothermic kidney perfusion – a scoping review - Verstraeten L, Den abt R, Ghesquière B, Jochmans, I. - 2023 - Journal of Clinical Medicine - PubMed

Unravelling metabolism during kidney perfusion using tracer studies, a systematic review - Gonzalez-Viedma, A., Van Dyck, R., De Beule, J., Ghesquière, B., Jochmans, I. - 2022 - Artificial Organs - PubMed

Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction - Adant, I., Bird, M., Decru, B., Windmolders, P., Wallays, M., de Witte, P., Rymen, D., Witters, P., Vermersch, P., Cassiman, D., Ghesquière, B - 2022 - Molecular Metabolism - PubMed

TraVis Pies: A Guide for Stable Isotope Metabolomics Interpretation Using an Intuitive Visualization - De Craemer, S., Driesen, K., Ghesquière, B - 2022 - Metabolites - Publication

Reprogramming of glucocorticoid receptor function by hypoxia - Vanderhaeghen, T., Timmermans, S., Watts, D., Paakinaho, V., Eggermont, M., Vandewalle, J., Wallaeys, C., Van Wyngene, L., Van Looveren, K., Nuyttens, L., Dewaele, S., Vanden Berghe, J., Lemeire, K., De Backer, J., Dikx, L., Vanden Berghe, W., Caljon, G., Ghesquière, B., De Bosscher, K., Wielockx, B., Palvimo, J.J., Beyaert, R., Libert, C. - 2021 - Embo Rep - PubMed

Macrophage-derived glutamine boosts satellite cells and muscle regeneration. - Shang M, Cappellesso F, Amorim R, Serneels J, Virga F, Eelen G, Carobbio S, Rincon MY, Maechler P, De Bock K, Ho PC, Sandri M, Ghesquière B, Carmeliet P, Di Matteo M, Berardi E, and Mazzone M - 2020 - Nature - PubMed

Oxygraphy Versus Enzymology for the Biochemical Diagnosis of Primary Mitochondrial Disease. - Bird, M.J., Adant, I., Windmolders, P., Vander Elst, I., Felguira, C., Altassan, R., Gruenert, S.C., Ghesquière, B., Witters, P., Cassiman, D., Vermeersch, P. - 2019 - Metabolites - Pubmed

The metabolic map into the pathomechanism and treatment of PGM1-CDG - Radenkovic S., Bird M., Emmerzaal TL., Sunnie YW., Felgueira C., Stiers KM., Leila S., Himmelreich N., Poschet G., Windmolders P., Verheijen J., Witters P., Altassan R., Honzik T., Eminoglu TF., James PM., Edmondson AC., Hertecant J., Tamas K., Thiel C., Vermeersch P., Cassiman D., Beamer L., Morava E., Ghesquière B. - 2019 - American Journal of Human Genetics - Pubmed

HIF-1 alpha metabolically controls collagen synthesis and modification in chondrocytes - Stegen S., Laperre K., Eelen G., Rinaldi G., Fraisl P., Torrekens S., Van Looveren R., Loopmans S., Bultynck G., Vinckier S., Meersman F., Maxwell PH., Rai J., Weis M., Eyre DR., Ghesquiere B., Fendt S-M., Carmeliet P., Carmeliet G - 2019 - Nature - Pubmed

Codon-specific translation reprogramming promotes resistance to targeted therapy - Rapino F., Delaunay S., Rambow F., Zhou Z., Tharun L., De Tullio P., Sin O., Shostak K., Schmitz S., Piepers J., Ghesquiere B., Karim L., Charloteaux B., Jamart D., Florin A., Lambert C., Rorive A., Jerusalem G., Leucci E., Dewaele M., Vooijs M., Leidel SA., Georges M., Voz M., Peers B., Buttner R., Marine JC., Chariot A., Close P. - 2018 - Nature - Pubmed

MAIMS: a software tool for sensitive metabolic tracer analysis through the deconvolution of C-13 mass isotopologue profiles of large composite metabolites - Verdegem D., Moseley HN B., Vermaelen W., Sanchez AA., Ghesquière B - 2017 - Metabolomics - Web of Science

Critical Assessment of Small Molecule Identification 2016: automated methods - Schymanski EL., Ruttkies C., Krauss M., Brouard C., Kind T., Duehrkop K., Allen F., Vaniya A., Verdegem D., Boecker S., Rousu J., Shen H., Tsugawa H., Sajed T., Fiehn O., Ghesquière B., Neumann S. - 2017 - Journal of Cheminformatics - Pubmed